Heparanase procoagulant activity is elevated in women using oral contraceptives
نویسندگان
چکیده
منابع مشابه
Heparanase procoagulant activity is elevated in women using oral contraceptives.
STUDY QUESTION What is the effect of estrogen on heparanase procogulant activity? SUMMARY ANSWER Estrogen increases heparanase procoagulant activity. WHAT IS KNOWN ALREADY Estrogen therapy increases the risk of thrombosis and was previously found to up-regulate heparanase expression. Heparanase is involved in angiogenesis and metastasis, and has been shown to form a complex with tissue fact...
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Considerable advances have been made in hormonal contraception in recent years, geared at maximizing compliance and minimizing discontinuation. In oral contraceptive (OC) formulations, the estrogenic component, generally ethinyl estradiol (EE), has been reduced significantly and newer progestins like dienogest and drospirenone (DRSP), compounds with different molecular structures, have been int...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2013
ISSN: 0268-1161,1460-2350
DOI: 10.1093/humrep/det257